Brothers with Recurrent Sinopulmonary Infections and Chronic Lung Disease
2019
Late diagnosis in patients with X-linked agammaglobulinemia (XLA) is associated with irreversible pulmonary complications such as bronchiectasis
Simple screening methods, such as serum protein fractions may be useful in suspecting of antibody deficiency
Medical treatment for XLA is by lifelong immunoglobulin replacement using Intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG)
Use of plasma for immunoglobulin substitution is dangerous due to possibility of transmission of blood-borne infections
It is necessary to remember the inexpediency of serological tests is suspicion of infections and using only direct methods of detecting the pathogen
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