Inhibition of oxaliplatin-induced neurotoxicity by silymarin through increased expression of brain-derived neurotrophic factor and inhibition of p38-MAPK

Backgrounds Oxaliplatinis a chemotherapeutic agent that induces neuropathy through unknown mechanisms and therefore, its pharmacological performance is limited. Silymarin, a well-known hepatoprotectivenatural flavonoid mixture, has neuroprotectiveeffects against certain neurodegenerative or neurotoxicstimuli.