Chromosome abnormalities in advanced stage T-cell lymphoblastic lymphoma of children and adolescents: a report from Japanese Paediatric Leukaemia/Lymphoma Study Group (JPLSG) and review of the literature

Summary T-cell acute lymphoblasticleukaemia ( T-ALL) and T-cell lymphoblastic lymphoma( T-LBL) are combined into one category as T lymphoblasticleukaemia/lymphoma in the current World Health Organization (WHO) classification. However, there is still ongoing discussion on whether T-ALL and T-LBL are two separate entities or represent two variant phenotypes of the same disease. Cytogeneticanalysis has been used to identify the molecular background of haematological malignancies. To compare the distribution of chromosomal abnormalities of T-ALL and T-LBL, large series of cytogeneticdata are required, but are absent in T-LBL in contrast to the abundant data in T-ALL. Among 111 T-LBL cases in our clinical trial, we obtained complete cytogeneticdata from 56 patients. The comparison between our cytogeneticfindings and those from three published T-LBL studies revealed no significant difference. However, meta-analysis showed that translocations involving chromosome region9q34 were significantly more common in T-LBL than in T-ALL. In particular, four out of the 92 T-LBL cases, but none of the 523 paediatric T-ALL cases, showed translocation t(9;17)(q34;q22–23) (P = 0·0004). Further studies are needed for the possible linkage between abnormal expression of genes located at 9q34 and/or 17q22–23 and the unique ‘lymphoma phenotype’ of T-LBL.