Primary malignant melanoma of the cervix: Report of a case with review of the literature

Malignant melanoma of the female genital tract is rare, and its localization in the cervix is exceptional, it represents 3% of malignant melanomas of the female genital tract, At the initial stage of malignant melanoma of the cervix, the disease is limited to the cervical mucosa, subsequently it spreads locally via direct diffusion to adjacent organs, Clinically there are asymptomatic cases diagnosed during a routine examination, However, more often one has the presence of symptoms, because the cervix ulceration expands easily and become infected. The most common symptom is vaginal bleeding. Macroscopically, primary malignant melanoma presents variable appearances, The spectrum of cellular characteristics is broad, Immunohistochemical markers may be positive in primary cervical malignant melanoma such as S-100, HMB-45, Melan-A, Vimentin, and SOX10, Differential Diagnosis of Primary Malignant Melanoma of the Cervix requires the exclusion of metastatic malignant melanoma, or other primary neoplastic site, mainly dermal, Once the diagnosis of malignant melanoma of the cervix is confirmed, the full staging of the disease should be establishment. This is based on performing a tomography (whole-body CT) or a positron emission tomography (PET / CT), the determination of serum lactate dehydrogenase.The therapeutic approach is not standardized but is rather individualized according to the characteristics of the disease and the patient.