EGFR Genotyping of Matched Urine, Plasma, and Tumor Tissue in Patients With Non–Small-Cell Lung Cancer Treated With Rociletinib, an EGFR Tyrosine Kinase Inhibitor
2018
PurposeLiquid biopsies represent an attractive alternative to tissue biopsies, particularly rebiopsies, in determining patient eligibility for targeted therapies. Clinical utility of
urinegenotyping, however, has not been explored extensively. We evaluated epidermal growth factor receptor (EGFR)
T790Mdetection in matched
urine, plasma, and tissue and the clinical outcomes of patients with advanced non–small-cell lung cancer treated with rociletinib.MethodsTissue (n = 540), plasma (n = 482), and
urine(n = 213) were collected from evaluable patients enrolled in
TIGER-X, a phase I/II study. Genotyping was performed by therascreen EGFR testing in tissue, BEAMing in plasma, and a quantitative short footprint assay (Trovera) in
urine, which was used to further examine discordant samples.ResultsPositive percent agreement with tissue
T790Mresults was similar for
urine(82%; 142 of 173) and plasma (81%; 313 of 387) genotyping.
Urineand plasma together identified more patients who were
T790Mpositive (92%) tha...
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