Bacteriologic epidemiology and empirical treatment of pediatric complicated appendicitis
2011
Abstract Preoperative samples in the context of complicated appendicitis (CA) are rarely collected, and there is no consensus regarding the optimal antibiotic therapy in children. To help optimize empirical preoperative treatment, we studied clinical and bacteriologic data from a prospective cohort of 93 children with CA in a French hospital. All the bacteria isolated from
peritoneal fluidswere identified, using phenotypic and/or molecular techniques. The most commonly recovered species were Escherichia coli (71%), Streptococcus group milleri (34%), anaerobes (20%), and Pseudomonas aeruginosa (19%). The association
piperacillin–tazobactamis an accurate choice of
empirical therapyas it is active against 97% of bacteria. A third-generation cephalosporin with
metronidazolein association with an
aminoglycosideis a good alternative. Although antibiotic use may be considered as an adjunct to surgical intervention of CA, the appropriate use of preoperative antibiotics is essential and must be constantly reevaluated according to the bacterial epidemiology.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
26
References
35
Citations
NaN
KQI