Non-invasive liver cancer ablation using histotripsy in an in vivo murine hepatocellular carcinoma (HCC) model

Current liver cancer ablationmethods are mainly thermal-based and inherently exhibit inconsistent tissue ablationdue to irregular heat dissipation. Histotripsyis a non-thermal ultrasound (US) ablationmethod that fractionates tissue through the precise control of acoustic cavitation. This paper studies the feasibility and chronic effects of non-invasive histotripsyfor liver cancer ablationin an in vivo murine HCC model.