Lentiviral interferon with immune checkpoint blockade: A novel method for gene therapy in bladder cancer.

Sharada Mokkapati,Andrea Kokorovic,Jonathan J. Duplisea,Devin Plote,Amy Lim,Vikram Narayan,Michael J. Metcalfe,Kenneth Dunner,Bogdan Czerniak,Tiina Nieminen,Tommi Heikura,Seppo Ylä-Herttuala,Nigel Parker,David J. McConkey,Colin P. Dinney

Lentiviral interferon with immune checkpoint blockade: A novel method for gene therapy in bladder cancer.

2020

Sharada Mokkapati
Andrea Kokorovic
Jonathan J. Duplisea
Devin Plote
Amy Lim
Vikram Narayan
Michael J. Metcalfe
Kenneth Dunner
Bogdan Czerniak
Tiina Nieminen
Tommi Heikura
Seppo Ylä-Herttuala
Nigel Parker
David J. McConkey
Colin P. Dinney

33Background: Gene therapy for bladder cancer (BLCA) is rapidly evolving. We reported that intravesical adenoviral interferon-alpha (Ad-IFNα) produced a complete response in 35% of patients with BC...

Keywords:

Immune checkpoint
Genetic enhancement
Cancer research
Blockade
Medicine
Pathology
Bladder cancer
Interferon
complete response

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