DNA-methylation abundantly associates with fetal alcohol spectrum disorder and its subphenotypes
2019
Aim:
Fetal alcohol spectrum disorder(FASD) involves prenatal
growth delay, impaired facial and CNS development and causes severe clinical, social-economic burdens. Here, we aim to detect DNA-methylation aberrations associated with FASD and potential FASD diagnostic and prognostic biomarkers. Patients & methods: The FASD diagnosis was established according to golden-standard protocols in a discovery and independent replication cohort. Genome-wide differential methylation association and replication analyses were performed. Results: We identified several loci that were robustly associated with FASD or one of its sub phenotypes. Our findings were evaluated using previously reported genome-wide surveys. Conclusion: We have detected robust FASD associated differentially methylated positions and
differentially methylated regionsfor FASD in general and for FASD subphenotypes, in other words on
growth delay, impaired facial and CNS development.
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