Assessment of the genomic stability and molecular landscape of patient-derived xenograft (PDX) models from NCI’s Patient-Derived Models Repository (PDMR).

Bishwajit Das,Yvonne A. Evrard,Li Chen,Rajesh Patidar,Corinne E. Camalier,Vivekananda Datta,Palmer Fliss,Michelle Gottholm-Ahalt,Erin Cantu,Gloryvee Rivera,Suzanne Borgel,John D. Carter,Margaret R. DeFreytas,Malorie Morris,Dianne L. Newton,Marianne Radzyminski,Melinda G. Hollingshead,Chris Karlovich,Paul M. Williams,James H. Doroshow

Assessment of the genomic stability and molecular landscape of patient-derived xenograft (PDX) models from NCI’s Patient-Derived Models Repository (PDMR).

2018

12023Background: Patient-derived xenografts (PDXs) are a powerful toolfor cancer translational research. However, it is unclear if early passage PDXs faithfully recapitulate the molecular profiles...

Keywords:

Genomic Stability
Oncology
Pathology
Internal medicine
Patient Derived Xenograft
Medicine
early passage
Cancer research
Translational research
Cancer

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