The biogenesis and biology of amyloid β oligomers in the brain.
2020
The repeated failure of clinical trials targeting the amyloid beta (Aβ) protein has challenged the amyloid cascade hypothesis. In this perspective, I discuss the biogenesis and biology of Aβ, from the arrangement of its atoms to its effects on the human brain. I hope that this analysis will help guide future attempts to home in on this elusive therapeutic target.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
49
References
5
Citations
NaN
KQI