Thermal Ablation of the Pancreas With Intraoperative High-Intensity Focused Ultrasound: Safety and Efficacy in a Porcine Model
2017
Abstract New focal destruction technologies such as
high-intensity focused ultrasound(HIFU) may improve the prognosis of pancreatic ductal adenocarcinoma. Our objectives were to demonstrate the safety and efficacy of intraoperative pancreatic HIFU
ablationin a porcine model. In a porcine model (N = 12), a single HIFU
ablationwas performed in either the body or tail of the pancreas, distant to
superior mesenteric vessels. All animals were sacrificed on the eighth day. The primary objective was to obtain an HIFU
ablationmeasuring at least 1 cm without premature death. In total, 12 HIFU
ablationswere carried out. These
ablationswere performed within 160 seconds and on average measured 20 (15-27) × 16 (8-26) mm. The primary objective was fulfilled in all but 1 pig. There were no premature deaths or severe complications.
High-intensity focused ultrasoundtreatment was associated with a transitory increase in amylase and lipase levels, and pseudocysts were observed in half of the pigs without being clinically apparent. All
ablationswere well delimited at both gross and histological examinations. Intraoperative thermal destruction of porcine pancreas with HIFU is feasible. Reproducibility and safety have to be confirmed when applied close to mesenteric vessels and in long-term preclinical studies.
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