The C. elegans Hox gene ceh-13 regulates cell migration and fusion in a non-colinear way. Implications for the early evolution of Hox clusters
2010
Background
Hox genesplay a central role in axial patterning during animal development. They are clustered in the genome and specify cell fate in sequential domains along the anteroposterior (A-
P)
bodyaxis in a conserved order that is co-linear with their relative genomic position. In the soil worm
Caenorhabditis elegans, this striking rule of co-linearity is broken by the anterior
Hox geneceh-13, which is located between the two middle Hox paralogs, lin-39 and mab-5, within the loosely organized nematode Hox cluster. Despite its evolutionary and developmental significance, the functional consequence of this unusual
genomic organizationremains unresolved.
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