The Hi-Culfite assay reveals relationships between chromatin contacts and DNA methylation state
2018
Hi-Culfite, a protocol combining Hi-C and
whole-genome bisulfite sequencing(WGBS), determines
chromatincontacts and DNA methylation simultaneously. Hi-Culfite also reveals relationships that cannot be seen when the two assays are performed separately. For instance, we show that loci associated with open
chromatinexhibit context-sensitive methylation: when their spatial neighbors lie in closed
chromatin, they are much more likely to be methylated.
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