The effect of intermittent fasting on blood pressure variability in patients with newly diagnosed hypertension or prehypertension

Abstract Background Intermittent fastingis a phenomenon which can be observed in most humans. The effect of intermittent fastingon blood pressure variability (BPV) has not previously been investigated. The purpose of this study was to assess the effect of fasting on BP (with office, home, central and ambulatory blood pressuremonitoring [ABPM]) and on BPV. Methods Sixty individuals were included in the study. Office, home, ABPM and central BP measurements were performed before and during intermittent fasting. Standard deviation (SD) and coefficient variation (CV) were used for office and home BPV measurement, while the smoothness index (SI) was used to calculate ABPM variability. Patients' BP and BPV values before and during intermittent fastingwere then compared. Results Intermittent fastingresulted in a significant decrease in office BP values and ABPM measurements but caused no significant change in home and central BP measurements. Twenty-four hour urinary sodium excretion decreased. SI values obtained from ABPM measurements were low, in other words, BPV was greater. BPV was higher in patients who woke up to eat before sunrise, but BPV was low in patients with high BMI. Conclusion Intermittent fastingproduced a significant decrease in BP values in termsof officeand ABPM measurements in this study, but caused no significant change in central BP and home measurements. We also identified an increase in BPV during intermittent fasting, particularly in patients who rose before sunrise.