Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline The Ohasama Study

Although an association between high blood pressureand cognitive declinehas been reported, no studies have investigated the association between home blood pressureand cognitive decline. Home blood pressuremeasurements can also provide day-to-day blood pressurevariability calculated as the within-participant SD. The objectives of this prospective study were to clarify whether home blood pressurehas a stronger predictive powerfor cognitive declinethan conventional blood pressureand to compare the predictive powerof the averaged home blood pressurewith day-to-day home blood pressurevariability for cognitive decline. Of 485 participants (mean age, 63 years) who did not have cognitive decline(defined as Mini-Mental State Examinationscore, P =0.03). However, conventional systolic blood pressurewas not significantly associated with cognitive decline( odds ratio, 1.24; P =0.2). The day-to-day variability in systolic blood pressurewas significantly associated with cognitive declineafter including home systolic blood pressurein the same model ( odds ratio, 1.51; P =0.02), whereas the odds ratioof home systolic blood pressureremained positive, but it was not significant. Home blood pressuremeasurements can be useful for predicting future cognitive declinebecause they can provide information not only on blood pressurevalues but also on day-to-day blood pressurevariability.