No association between gluten sensitivity and amyotrophic lateral sclerosis
2017
To examine evidence for a role of
glutensensitivity (GS) or celiac disease (CD) in ALS etiology, we included participants from a population-based case–control study in The Netherlands between January 2006 and December 2015. We compared levels and seroprevalence of IgA antibodies to
tissue transglutaminase6 (TG6) in 359 ALS patients and 359 controls, and to transglutaminase 2 (TG2) and
endomysium(EMA) in 199 ALS patients and 199 controls. Questionnaire data on 1829 ALS patients and 3920 controls were examined for CD or
gluten-free diets (GFD).
Genetic correlationand HLA
allele frequencieswere analyzed using two genome-wide association studies: one on ALS (12,577 cases, 23,475 controls), and one on CD (4533 cases, 10,750 controls). We found one patient with TG6, TG2 and EMA antibodies who had typical ALS and no symptoms of GS. TG6 antibody concentrations and positivity, CD prevalence and adherence to a GFD were similar in patients and controls (p > 0.66) and in these patients disease progression was compatible with typical ALS. CD and ALS were not found to be
genetically correlated(p > 0.37). CD-associated HLA
allele frequencieswere similar in patients and controls (p > 0.28). In conclusion, we found no serological evidence for involvement of
gluten-related antibodies in ALS etiology nor did we observe an association between CD and ALS in medical
historyor
geneticdata, indicating that there is no evidence in our data for an association between the two diseases. Hence, a role for a GFD in the ALS treatment seems unlikely.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
-
Machine Reading By IdeaReader
33
References
3
Citations
NaN
KQI