CCR 20th Anniversary Commentary: Immune-Related Response Criteria—Capturing Clinical Activity in Immuno-Oncology
2015
To evaluate antitumor responses to chemotherapeutic agents, investigators would typically rely upon
Response Evaluation Criteriain
Solid Tumors(RECIST) or modified WHO criteria, which do not comprehensively capture responses with immunotherapeutic agents. In the December 1, 2009, issue of Clinical
Cancer Research, Wolchok and colleagues reported their development of novel criteria, designated “
Immune-related Response Criteria” (irRC), designed to better capture the response patterns observed with immunotherapies. Broad use of the irRC since then has allowed for a more comprehensive evaluation of immunotherapies in clinical trials, indicating that their concepts can be used in conjunction with either RECIST or WHO, and has shown irRC to be a powerful tool for improved
clinical investigation. Clin Cancer Res; 21(22); 4989–91. ©2015 AACR . See related article by Wolchok et al., Clin Cancer Res 2009;15(23) December 1, 2009;7412–20
Keywords:
-
Correction
-
Source
-
Cite
-
Save
14
References
41
Citations
NaN
KQI