Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System)
2015
Background/Aims: The aim of this study was to determine the correlation between low-dose
ramosetronpretreatment and gastric
emptyingusing a novel, non-invasive technique for measuring gastric
emptying,
namely, the continuous real-time 13C
breath test(BreathID system: Exalenz Bioscience Ltd., Israel). Materials and Methods: Twelve healthy male volunteers participated in this randomized two-way
crossover study. The subjects fasted overnight and were randomly assigned to receive the test meal (200 kcal per 200 mL) after an hour pre-treatment with 5 µg
ramosetronor the test meal alone. Gastric
emptyingwas monitored for 4 hours after administration of the test meal with the 13C-acetic acid
breath testperformed continuously using the BreathID system. Using Oridion Research Software (β version), T 1/2, T lag, GEC and the regression-estimated constants (β and κ) were calculated. The differences in the parameters measured at two time-points were analyzed using Wilcoxon’s signed-rank test. Results: There was a significant difference in the calculated parameter β. No significant differences in the calculated parameters T 1/2, T lag, GEC or κ were observed between the test meal with
ramosetrongroup and the test meal alone group. Conclusion: This study showed that
ramosetronpre-treatment enhances the early gastric
emptyingof liquid nutrients.
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