Tedizolid as step-down therapy following daptomycin versus continuation of daptomycin against enterococci and Staphylococcus aureus (MRSA/VRSA) in a rat endocarditis model

Tedizolid and daptomycin were assessed in a rat endocarditis model against Enterococcus faecalis, Enterococcus faecium (VAN(R), AMP(R)), and Staphylococcus aureus In monotherapy, TZD 5d was not effective compared to no treatment controls while DAP 5d was significantly effective against these bacteria. Step-down therapy (DAP 3d followed by TZD 2d) was as effective as DAP 5d and was comparable to 3d of DAP+ceftriaxone and to 3d of DAP+gentamicin.