Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny
2018
Antenatal inflammation as seen with
chorioamnionitisis harmful to foetal/neonatal
organ developmentincluding to eyes. Although the major pro-inflammatory cytokine IL-1β participates in retinopathy induced by
hyperoxia(a predisposing factor to
retinopathyof
prematurity), the specific role of antenatal IL-1β associated with preterm birth (PTB) in retinal vasculopathy (independent of
hyperoxia) is unknown. Using a murine model of PTB induced with IL-1β injection in utero, we studied consequent retinal and choroidal vascular development; in this process we evaluated the efficacy of IL-1R antagonists. Eyes of foetuses exposed only to IL-1β displayed high levels of pro-inflammatory genes, and a persistent postnatal infiltration of inflammatory cells. This prolonged inflammatory response was associated with: (1) a marked delay in retinal vessel growth; (2) long-lasting thinning of the choroid; and (3) long-term morphological and functional alterations of the retina. Antenatal administration of IL-1R antagonists – 101.10 (a modulator of IL-1R) more so than Kineret (competitive IL-1R antagonist) – prevented all deleterious effects of inflammation. This study unveils a key role for IL-1β, a major mediator of
chorioamnionitis, in causing sustained ocular inflammation and perinatal vascular
eye injury, and highlights the efficacy of antenatal 101.10 to suppress deleterious inflammation.
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