Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy
2018
We examined the effect of a combination of
astaxanthin(AX) supplementation, repeated heat stress, and intermittent reloading (IR) on satellite cells in unloaded rat
soleus muscles. Forty-nine male Wistar rats (8-week-old) were divided into control, hind-limb unweighting (HU), IR during HU, IR with AX supplementation, IR with repeated heat stress (41.0–41.5 °C for 30 min), and IR with AX supplementation and repeated heat stress groups. After the experimental period, the antigravitational
soleus musclewas analyzed using an immunohistochemical technique. Our results revealed that the combination of dietary AX supplementation and heat
stress resultedin protection against disuse
muscle atrophyin the
soleus muscle. This protective effect may be partially due to a higher satellite cell number in the
atrophied
soleus musclein the IR/AX/heat stress group compared with the numbers found in the other groups. We concluded that the combination treatment with dietary AX supplementation and repeated heat stress attenuates
soleus muscle
atrophy, in part by increasing the number of satellite cells.
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