Tumor necrosis factor-related apoptosis inducing ligand and its receptors in hepatocellular carcinoma

Tumor necrosis factor-related apoptosis inducing ligands (TRAILs) and their receptors can specifically express in hepatocellular carcinoma cells.TRAIL can specifically induce tumor cells apoptosis through death receptors (DRs) ; TRAIL combined radiation and chemotherapy can effectively overcome the TRAIL resistance of tumor cells,and promote the apoptosis of tumor cells,meanwhile the gene therapy of TRAIL on anti-tumor clinical treatment has been widely used. Key words: TNF-related apoptosis-inducing ligand ; Receptors, TNF-related apoptosis-inducing ligand ; Liver neoplasms