Prorenin Levels in Retinopathy of Prematurity

Purpose To evaluate serum prorenin levels in preterm infants with or without retinopathyof prematurity(ROP). Design Noncomparative retrospective case control study. Methods Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kineticassay. Results The mean prorenin concentrations were higher in preterm infants with ROP than in infants without ROP at every time point: from 26 to 30 weeks, 2326 ± 334 μg/ml (mean ± SE [ standard error]) (n = 3) and 1164 ± 234 μg/ml (n = 3), respectively ( P P P Conclusions Prorenin levels in preterm infants can predict which infants will develop ROP.