Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study

2018
AbstractObjectives: The risk for recurrent primary sclerosing cholangitis(rPSC) after liver transplantationis associated with inflammatory bowel disease (IBD). We assessed the frequency of rPSC and studied risk factors for recurrent disease with special focus on IBD. We also evaluated the importance of rPSC for prognosis.Materials and methods: All liver transplantedPSC patients in the Nordic countries between 1984 and 2007 (n = 440), identified by the Nordic Liver TransplantRegistry, were studied. Data were retrieved from patients' chart reviews. Multivariable Cox regression models were used to calculate risk factors for rPSC and death.Results: Of the 440 patients with a follow-up time after liver transplantationof 3743 patient years, rPSC was diagnosed in 19% (n = 85). Colectomybefore liver transplantationwas associated with a reduced risk of rPSC (HR 0.49; 95% CI, 0.26–0.94, p = 0.033). Neither high IBD activity nor presence of IBD flares before or after liver transplantationwas associated with ...
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