Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD.

Acaris Benetti,F. Martins,Letícia de Barros Sene,Maria Heloisa Massola Shimizu,Antonio Carlos Seguro,Weverton Machado Luchi,Adriana C. C. Girardi

Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD.

2020

Acaris Benetti
F. Martins
Letícia de Barros Sene
Maria Heloisa Massola Shimizu
Antonio Carlos Seguro
Weverton Machado Luchi
Adriana C. C. Girardi

This study investigated the molecular mechanisms underlying the antiproteinuric effect of DPP4 inhibition in 5/6 renal ablation rats and tested the hypothesis that the urinary activity of DPP4 corr...

Keywords:

Biomarker (medicine)
Urology
Podocin
Proximal tubule
renal ablation
Dipeptidyl peptidase-4
Proteinuria
Urinary system
Medicine

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