A gyűjtőcsatorna meghatározó szerepe a vese lokális renin-angiotenzin rendszerében | The cortical collecting duct plays a pivotal role in kidney local renin-angiotensin system

A renin-angiotenzin rendszer szervezetunk egyik legjelentősebb hormonalis rendszere, amelynek juxtaglomerularis apparatusban tortenő szabalyozasa es szerepe jol ismert. Jelen osszefoglalo a vese embrionalis fejlődesevel parhuzamot allitva a gyűjtőcsatorna renintermeleset irja le, valamint ennek lokalis szerepet es terapias celpontkent szolgalo lehetősegeit igyekszik feltarni. Nemregiben kerult leirasra, hogy kronikus angiotenzin-II-kezeles soran, ket vese-, egy klip modellben, illetve diabetes mellitusban a gyűjtőcsatorna jelenti az intrarenalis (pro)renintermeles legfőbb helyet. Ebben a lokalizacioban a (pro)renin előtt ut nyilhat az interstitialis renin-angoitenzin rendszer komponensek, a szisztemas keringes es a nemregiben leirasra kerult (pro)reninreceptor fele. A (pro)renin sajat receptoran keresztul intracellularis profibroticus utakat kepes aktivalni, igy egyuttal potencialisan uj celpontja lehet a hypertoniahoz kapcsolodo vagy diabeteses nephropathia kezelesenek, illetve eszkoze a kronikus vesekarosodast előidező folyamatok korai diagnosztizalasanak. Orv. Hetil., 2013, 154, 643–649. | The renin-angiotensin system is one of the most important hormone systems in the body, and the regulations as well as the role in the juxtaglomerular apparatus are well known. The present review focuses on renin secretion in a recently described localization, the cortical collecting duct. The authors display it in parallel of the copying strategy of an adult and a developing kidney. Furthermore, based on different animal studies it highlights the local role of renin released from the collecting duct. In chronic angiotensin II-infused, 2-kidney, 1-clip hypertensive model as well as in diabetic rats the major source of (pro)renin is indeed the collecting duct. In this localization this hormone can reach both the systemic circulation and the interstitial renin-angiotensin system components including the newly described (pro)renin receptor, by which (pro)renin is able to locally activate pro-fibrotic intracellular signal pathways. Consequently, one can postulate that in the future renin may serve either as a new therapeutic target in nephropathy associated with both hypertension and diabetes or as an early diagnostic marker in chronic diseases leading to nephropathy. Orv. Hetil., 2013, 154, 643–649.