Clinical utility of the K-T cancellation test in a memory clinic population

ABSTRACTBackground/Aim: The K-T cancellation test (K-T) has been validated as a measure of executive functions (EF) but its clinical utility has not yet been examined. This study aimed to validate K-T in a memory clinicsetting by examining its capacity to discriminate older adults with normal cognition (NC) from those with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Method: K-T was administered to 120 NC subjects, 146 patients with MCI, and 93 patients with AD. A one-way analysisof covariancewas used to compare the correct cancellations of K-T between the groups. Linear regressions were run to identify significant demographic predictors of K-T for NC subjects and to determine the equation to calculate z scores for all subjects. The area underthe curve(AUC), sensitivity (Se), specificity (Sp), and positive (PPV) and negative (NPV) predictive values were assessed to compare the diagnostic performance between K-T and the Mini-Mental State Examination(MMSE) for discrimination between N...