Visceral adiposity index (VAI), lipid accumulation product (LAP), and product of triglycerides and glucose (TyG) to discriminate prediabetes and diabetes
2019
The present study evaluated the ability of the visceral adiposity index (VAI), the lipid accumulation product (
LAP), and product of triglycerides and glucose (TyG), three novel, insulin resistance-related markers, to discriminate
prediabetes/diabetes in the general
German population. Altogether 2,045 Germans (31–72 years, 53.3% women) without known diabetes and a history of Myocardial Infarction (MI)/stroke from the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study were eligible. The discriminatory accuracy of the markers for oral glucose tolerance test (OGTT)-defined
prediabetes/diabetes according to the American Diabetes Association (ADA) criteria was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). The Youden Index (YI) was used to determine optimal cut-off values, and a non-parametric ROC regression was used to examine whether the discriminatory accuracy varied by sex and age. 365 men (38.2%) and 257 women (23.6%) were newly diagnosed with
prediabetes/diabetes. AUCs for TyG,
LAPand VAI were 0.762 (95% CI 0.740–0.784), 0.743 (95% CI 0.720–0.765), and 0.687 (95% CI 0.662–0.712), respectively. The optimal cut-off values for the
LAPand TyG were 56.70 and 8.75 in men, and 30.40 and 8.53 in women. In conclusion, TyG and
LAPprovide good discrimination of persons with
prediabetes/diabetes.
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