Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
2019
Gross
Chromosomal Rearrangements(GCRs) play an important role in human diseases, including cancer. Although most of the nonessential
Genome InstabilitySuppressing (GIS) genes in Saccharomyces cerevisiae are known, the
essential genesin which mutations can cause increased GCR rates are not well understood. Here 2 S. cerevisiae GCR assays were used to screen a targeted collection of
temperature-sensitive mutantsto identify mutations that caused increased GCR rates. This identified 94 essential GIS (eGIS) genes in which mutations cause increased GCR rates and 38 candidate eGIS genes that encode eGIS1 protein-interacting or family member proteins. Analysis of TCGA data using the human
genes predictedto encode the proteins and protein complexes implicated by the S. cerevisiae eGIS genes revealed a significant enrichment of mutations affecting predicted human eGIS genes in 10 of the 16 cancers analyzed.
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