In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study.

Abstract Purpose To establish that a magnetic device designed for intravascular use can bind small iron particles in physiologic flow models. Materials and Methods Uncoated iron oxide particles 50–100 nm and 1–5 µm in size were tested in a water flow chamber over a period of 10 minutes without a magnet (ie, control) and with large and small prototype magnets. These same particles and 1-µm carboxylic acid–coated iron oxide beads were likewise tested in a serum flow chamber model without a magnet (ie, control) and with the small prototype magnet. Results Particles were successfully captured from solution. Particle concentrations in solution decreased in all experiments ( P Conclusions This study demonstrates the concept of magnetic capture of small iron oxide particles in physiologic flow models by using a small wire-mounted magnetic filter designed for intravascular use.