Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ
2018
Drug resistanceis a major cause of treatment failure in
pancreatic cancer. The limited evidence indicates the involvement of
miR-455-3p in chemotherapy resistance of cancer. Here we observed by qPCR that
miR-455-3p was significantly decreased in
pancreatic cancertissues and cell lines. We then confirmed that the inhibition of
miR-455-3p increased cell proliferation and
gemcitabineresistance of
pancreatic cancer, whereas forced overexpression of
miR-455-3p had the opposite effect. Furthermore, we demonstrated that TAZ, which is associated with
drug resistanceof
pancreatic cancer, is a new direct downstream target of
miR-455-3p. Our present study suggests that
miR-455-3p contributes to cell proliferation and
drug resistancein
pancreatic cancercells via targeting TAZ.
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