Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice

The use of iPSCs to generate hematopoietic stem/progenitor cells (HSPC) is of considerable therapeutic interest, as allogeneic HSPC transplantation is limited by the lack of compatible donors, a high risk of engraftment failure and GVHD. Efficacy and safety assessments are required and non-human