Risk factors for decline in renal function among young adults with type 1 diabetes

Abstract Aims To investigate risk factors for declining renal function among subjects with type-1-diabetes. Methods Observational study based on data from the diabetes registry DPV. 4424 type-1-diabetessubjects aged ≥18 years, age at onset Results Median age was 26 [Q1; Q3: 21; 39] years. Annual decline of renal function was −1.22 (95% CI: −1.50; −0.94) ml/min/1.73 m 2 . At baseline, higher eGFR was related to more rapid decline compared to impaired or reduced eGFR (GFR ≥ 90: −2.06 (−2.35; −1.76), 60 ≤ GFR  2 , p p p  = 0.04), hypertension (p  p  = 0.03) were associated with more rapid loss of kidney function. No difference was observed among insulin regimen. Conclusion Among this large type-1-diabetescohort, more rapid loss of kidney function was related to higher baseline eGFR, log-term worse metabolic control and diabetic comorbidities.