Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8 + T cells

ZIKV-specific and ZIKV/DENV cross-reactivehuman HLA epitopesare identified in naive and DENV-immune mice, revealing altered immunodominancein the DENV-immune setting and a protective role for epitope-specific CD8+ T cells against ZIKV.