Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes
2012
Tony Lam and his colleagues show that the middle intestine senses glucose and has a role in a gut-brain-liver axis to regulate hepatic glucose production. They also show that an experimental form of bariatric surgery quickly ameliorates hyperglycemia in two rat models of type 1 diabetes, and the intestinal sensing of glucose they have identified probably contributes to this metabolic effect.
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