The sea urchin kinome: a first look.
2006
This paper reports a preliminary in silico analysis of the
sea urchin
kinome. The predicted protein
kinasesin the
sea urchingenome were identified, annotated and classified, according to both function and
kinasedomain taxonomy. The results show that the
sea urchin
kinome, consisting of 353 protein
kinases, is closer to the Drosophila
kinome(239) than the human
kinome(518) with respect to total
kinasenumber. However, the diversity of
sea urchin
kinasesis surprisingly similar to humans, since the urchin
kinomeis missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the
sea urchin
kinomecombines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the
sea urchin
kinasesare involved with signal transduction, and approximately 88% of the signaling
kinasesare expressed in the developing embryo. These results support the strength of this nonchordate
deuterostomeas a pivotal developmental and evolutionary
model organism.
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