Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings

18F-AV-1451 is a tau PET radioligand, characterized by high affinity for paired helical filaments (PHF) of hyperphosphorylated tau in neurofibrillary tangles (NFTs). Postmortem tissue studies have shown AV-1451 binding selectively to tau (3R + 4R isoforms) but not β-amyloid pathology.1–3 Human studies evaluating AV-1451 tracer retention in aging and Alzheimer disease (AD) have indicated that in vivo binding patterns parallel existing neuropathologic staging of tau.4,5