Connective tissue diseases and pregnancy
2006
Connective tissue diseases(
CTD) such as systemic
lupus erythematosusdiffuse or limited systemic sclerosis and numerous others affect women frequently during the childbearing period. Every pregnancy in a patient with
CTDshould be regarded as high-risk pregnancy, and requires intensive monitoring and immediate treatment of clinical problems. For these reasons, for women suffering from
CTD, who are pregnant or who intend to become pregnant, an interdisciplinary setting addressing all aspects of
rheumatology, ob-gyn and neonatalogy needs to be provided. This setting includes particular diagnostic tools and laboratory parameters prior to and during pregnancy as well as in the post-partal period. Aside overt
organ dysfunction, key problems in pregnant
CTDpatients consist mainly of haemostaseological problems such as antiphospholipid antibodies,
neonatal lupus erythematosus, congenital
heart blockand drug therapy of the underlying disease, which will be outlined in this review.
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