Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT

ABSTRACT Non-graft-versus-host disease (GVHD) ocular complicationsare generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complicationsin a collaboration between transplantation physicians and ophthalmologists through the Late Effectsand Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant ComplicationsWorking Party of the European Society of Blood and Marrow Transplantation. Complicationsdiscussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. We summarize the incidence, risk factors, screening, prevention, and treatment of individual complicationsand generate evidence-based recommendations. Baseline ocular evaluation before HCT should be considered in all patients who undergo HCT. Follow-up evaluations should be considered according to clinical signs and symptoms and risk factors. Better preventive strategies and treatments remain to be investigated for individual ocular complicationsafter HCT. Both transplantation physicians and ophthalmologists should be knowledgeable about non-GVHD ocular complicationsand provide comprehensive collaborative team care.