Randomized Trial of Pleural Fluid Drainage Frequency in Patients with Malignant Pleural Effusions. The ASAP Trial

Rationale: Patients with malignant pleural effusionshave significant dyspnea and shortened life expectancy. Indwelling pleural catheters allow patients to drain pleural fluid at home and can lead to autopleurodesis. The optimal drainagefrequency to achieve autopleurodesis and freedom from catheter has not been determined.Objectives: To determine whether an aggressive daily drainagestrategy is superior to the current standard every other day drainageof pleural fluid in achieving autopleurodesis.Methods: Patients were randomized to either an aggressive drainage(daily drainage; n = 73) or standard drainage(every other day drainage; n = 76) of pleural fluid via a tunneled pleural catheter.Measurements and Main Results: The primary outcome was the incidence of autopleurodesis following the placement of the indwelling pleural catheters. The rate of autopleurodesis, defined as complete or partial response based on symptomatic and radiographic changes, was greater in the aggressive drainagearm than the sta...