Sterculia diversifolia bears anti-cancer and immunomodulatory activities

The present study was aimed to evaluate the methanolic extract and subsequent solvents soluble fractions of Sterculia diversifolia bark for cytotoxic, anti-cancer and immunomodulatory activities. Phytochemical investigation confirmed the presence of alkaloids, flavonoids, saponins, glycosides, etc. In the cytotoxic activity, n-hexane showed potent activity (LD 50 : 7.0 µg/mL) followed by dichloromethane fraction (LD 50 : 16.2 µg/mL). In the anti-cancer activity, dichloromethane fraction showed potent activity (IC 50 : 5.9 µg/mL) followed by ethyl acetate fraction (IC 50 : 9.5 µg/mL). While in the immunomodulatory assay, ethyl acetate fraction showed a very significant activity (IC 50 : 21.0 µg/mL) followed by dicloromethane and n-butanol fractions (IC 50 : 25.0 and 25.3 µg/mL respectively). Hence, it is clear that S. diversifolia has anti-cancer and immunomodulatory agents. Video Clip of Methodology : ROS Assay: 2 min 9 sec Full Screen Alternate