Breast Cancer Detection in a Screening Population: Comparison of Digital Mammography, Computer-Aided Detection Applied to Digital Mammography and Breast Ultrasound.

by US (96.5%) or FFDM+CAD+US (100%) was superior to that of FFDM (87.1%) (p= 0.019 or p< 0.001, respectively) or FFDM+ CAD (88.3%) (p= 0.050 or p< 0.001, respectively). However, cancer detectability was not significantly different between FFDM versus FFDM+CAD (p = 1.000) and US alone versus FFDM+CAD+US (p= 0.126). The tumor size influenced cancer detectability by all imaging modalities (p< 0.050). In FFDM and FFDM+CAD, the nondetecting group consisted of younger patients and patients with a denser breast composition (p< 0.050). In breast US, carcinoma in situ was more frequent in the nondetecting group (p= 0.014). Conclusion: For breast cancer screening, breast US alone is satisfactory for all age groups, although FFDM+ CAD+US is the perfect screening method. Patient age, breast composition, and pathological tumor size and type may influence cancer detection during screening.