Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
2015
Transgenic mice that express the
cytosine deaminaseAID develop precancerous
pancreaticlesions without the apparent involvement of
oncogenes, offering a unique mouse model of
pancreaticcancer to analyze mutations involved in later stages of
pancreatic
carcinogenesis.
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