Immunohistochemical detection of hTERT in urothelial lesions: a potential adjunct to urine cytology

2006 
Urine cytology has a critical role in evaluation for bladder carcinoma. Due to the low sensitivity of this technique, ancillary modalities such as the detection of markers of malignancy by immunochemistry are desirable. Promising factors in this context are components of the human telomerase enzyme complex. Telomerase repairs and extend telomeres, which when eroded beyond a critical limit trigger a senescence checkpoint. Accordingly, while absent in normal somatic cells, telomerase activity has been detected in the great majority of malignant tumor specimens tested, and so has potential value for the recognition of malignant cells in clinical specimens.
    • Correction
    • Source
    • Cite
    • Save
    34
    References
    25
    Citations
    NaN
    KQI
    []
    Baidu
    map