A study of sirolimus and an mTOR kinase inhibitor (TORKi) in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease (ADPKD)

Autosomal dominant polycystic kidney disease(ADPKD) is characterized by cyst formation and growth, which is partially driven by abnormal proliferation of tubular cells. There is activation of the ...