A study on the correlation of Posner-Schlossman syndrome with the genetic diversity of killer immunoglobin-like receptors and HLA ligands

Objective To investigate the correlation of Posner-Schlossman syndrome (PSS) with the diversity of killer immunoglobin-like receptors(KIR) gene and its ligands.Methods 97 PSS patients and 100 randomly-selected healthy controls were subjected to detecting the presence or absence of each KIR frame gene by PCR-SSP and the sequencing-based typing at HLA-A,-B and-C loci.Statistical analyzing the differences in the frequencies of the each KIR frame gene,KIR haplotype group,HLA ligands and each known KIR-HLA complex between healthy control group and patients.Results There is no significant different between the frequency of KIR frame gene and haplotype in PSS patients comparing with the controls; while the frequency of HLABw4-80T was 22.1％ and 41.0％ (P ＜ 0.01),3DL1 + HLA-Bw4-80T was 22.1％ 和40.0％ (P ＜ 0.05) in PSS patients,healthy controls,respectively.There is significantly different between PSS patients and healthy controls.Conclusion No relationship between KIR and PSS,the associations between HLA ligand or KIR-HLA and PSS may be useful for further study on the mechanism of PSS. Key words: Posner-Schlossman syndrome; Killer immunoglobulin-like receptors;  Human leukocyte antigens ;  Ligand ;  Gene diversity