A time-domain fluorescence diffusion optical tomography system for breast tumor diagnosis
2011
A prototype time-domain fluorescence diffusion optical tomography (FDOT) system using near-infrared light is
presented. The system employs two pulsed light sources, 32 source fibers and 32 detection channels, working separately
for acquiring the temporal distribution of the photon flux on the tissue surface. The light sources are provided by low
power picosecond pulsed diode lasers at wavelengths of 780 nm and 830 nm, and a 1×32-fiber-optic-switch sequentially
directs light sources to the object surface through 32 source fibers. The light signals re-emitted from the object are
collected by 32 detection fibers connected to four 8×1 fiber-optic-switch and then routed to four time-resolved
measuring channels, each of which consists of a collimator, a filter wheel, a photomultiplier tube (PMT)
photon-counting head and a time-correlated single photon counting (TCSPC) channel. The performance and efficacy of
the designed multi-channel PMT-TCSPC system are assessed by reconstructing the fluorescent yield and lifetime
images of a solid phantom.
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