S100-alarmin-induced innate immune programming protects newborn infants from sepsis
2017
Neonates are thought to have impaired immune responses, yet, paradoxically, they can also demonstrate hyperinflammation. Ulas et al. show that a neonatal burst of the alarmins
S100A8and
S100A9activates a distinct innate immune response without dangerous hyperinflammation.
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