Intermediate-Term Efficacy and Tolerance of Statins in Children

Objectives To evaluate the intermediate-term efficacy and tolerance of statins in children and adolescents with familial hypercholesterolemia. Study design A total of 131 children or adolescents treated with statins for familial hypercholesterolemia were prospectively included. The efficacy of treatment was established by the percentage of children who achieved low density lipoprotein-cholesterol (LDL-C) levels Results The median duration of treatment with statins was 4 years. A median decrease of 32% in LDL-C levels was observed ( P Conclusions The results of this large cohort confirm the intermediate-term safety and efficacy of statin therapy in children with familial hypercholesterolemia.